An Enzyme That Builds Telomeres

Carol Greider, an American molecular biologist, along with her administrator Elizabeth Blackburn began to investigate if the formation of telomere DNA could be due to an unknown enzyme.

On December 25th, 1984, Greider identified the signs of enzymatic activity in a cell extract. Elizabeth Blackburn (an Australian-American Nobel laureate) named the enzyme telomerase, purified it, and showed it consists of Ribonucleic Acid (RNA) as well as protein. The RNA component turned out to contain the CCCCAA sequence.

It serves as the template for when the telomere is built, while the protein component is necessary for the construction work, such as; enzymatic activity. Telomerase extends telomere DNA, providing a platform which enables DNA polymerases to copy the entire length of the chromosome without missing the very end portion.

Each cell in the human body’s reproductive system holds telomerase. However, the telomerase enzyme is switched off by a receptor block. By using a telomerase activating molecule, such as TAM 818, the telomerase enzyme in human cells, is attracted to the TAM 818 active molecule.

This allows the body to naturally express telomerase – allowing human cells to divide, telomeres to shorten and re-lengthen slightly, therefore, reversing the physical signs of ageing in the human body. The division of cells in the human body and the shortening of the enzyme telomerase has been proven to have a direct link in the process of ageing and age-related diseases.

The shortening of telomeres in the human body is what gives away the physical signs of our age. By successfully extending the length of the telomerase enzyme, we are able to achieve and reverse the cycle of premature ageing.

About The Author

Branka Duric

Beauty Editor experienced in writing on Fashion, Beauty, Health & Skincare.