Dr. Bill Andrews Talk – Part 3

Hear more of Dr. Bill Andrews’ talk on Curing Aging….

I was awarded as I mentioned before, award is second place for the United States Inventor of the Year for this discovery which was a big discovery. My colleagues won the Nobel Prize in Medicine for this discovery. So it’s, its been getting a lot of attention, its, lot of people are touting this as possibly the biggest medical breakthrough of all time as soon as we can actually do something with it, ok. Where we can actually give people a pill to treat their problems. But right now, this is very exciting in the scientific world.

So let’s go back to this brick laying model. What’s happening? How’s telomerase doing this? Well, in the, in a reproductive cell, that bricklayer is still going to fall off at the end of the wall. But like an angel, plumbers comes in and replaces that brick. And as a result, the telomeres don’t get shorter.

Now I want to get ahead of the game, we have shown that if we put more telomerase in the cells, the telomeres actually get longer, which is suggestive of a reverse in aging. And that’s how we’re, that’s how we’re trying to approach this is trying to overproduce telomeres in our cells to reverse aging.

So there’s two words that I’ve come up with that I’ve mentioned today, telomerase and telomere. A lot of people get those mixed up, I just wanted, so you’re really clear, to make it clear, telomerase is the enzyme that lengthens the telomere. So the telomeres at the tip of your chromosome, enzyme telomerase, telomeres’ at the tip of your chromosomes, telomerase is the enzyme that relengthens them. Alright, what would happen if we were to put telomerase in all the cells in the body?

Before I go further, I do have a question, I do have a book for. Anybody here who like, like I’m going to ask a question, but if you obviously know it because you listened to a previous talk or something like that you probably shouldn’t answer. So if somebody who isn’t, isn’t here, doesn’t know the answer, how, how long do lobsters live? Anybody know how long a lobster lives? Ok, so, so now since nobody answered the question, how about anybody who wants to answer it, answer it. Anybody? Huh? So that’s the answer right now. It’s they have undetectable aging, yeah. So here’s your book.

It’s been known for a long time or let’s say for a long time, at least 150 years has been the people have been asking the question, how long do animals live. Before days of Darwin nobody cared about that kind of stuff. But people after Darwin started collecting animals. Now the problem is that most animals don’t have things like rings on a tree so you can’t count them to figure out how old they are. So the only way to figure out how a lobster will live or some other animal is to catch them when they’re born, put them in a crustacean aquarium and watch them.

Well a hundred and fifty years later, lobsters are showing no signs of aging. And it was published recently, too many clicks, hold on, it was published that the reason why lobsters show no signs of aging is because they have telomerase produced in all their cells, not just the reproductive cells. They have it in every single cell in their body.

Now remember I also said that, that short telomeres increase your risk of cancer. It’s also been published, this, these things they’re not work right. Ok, it’s also been published now that lobsters rarely get cancer and other diseases. It’s all because of the fact their telomeres don’t get the, get short. There, they have telomerase produced in all their cells. They don’t have telomere shortening. They show no signs of aging and they rarely get diseases. This is a good thing. I want to us to all be like these lobsters. Now, of course, lobsters do have a lot, a bunch of other ways to die. This doesn’t make them an immortal. They still get eaten by everybody who likes lobsters. But there’s other animals too, that have now been identified to fit in that same category; tortoises, clams, humpback whales, fish, even some birds have been shown to have no detectable aging.

Now Charles Darwin had a pet tortoise named Harriet and she just died recently at a hundred and eighty years old. And by the way, when I give this presentation yesterday, somebody in the audience raised their hands up, I’ve met Harriet. I don’t know if anybody here has, apparently she was in a zoo here in New Zealand.

Australian Zoo.

Oh, Australian zoo? Ok. So, but she didn’t, she died of a viral infection of some kind, not, not from aging. And there’s also tortoises on this planet that are over 200 years old documented to be over 200 years old and they don’t look like old tortoises. They just, they’re bigger, but they, they’re still healthy.

There was a whale found with a harpoon in it and they carbon-dated the harpoon and found out that the harpoon was a hundred and thirty years old. How is that whale, I mean it had to be big enough to throw a harpoon into when it was a hundred thirty years ago. So it’s definitely older than that.

Now, I’d mentioned that none of the animals have rings on a tree like, things like rings on a tree that you can count. The exception is clams. So people started realizing that the number of stripes, each stripe represents a year on those clams, if you look at the top right picture.

So this is Ming, the clam. She’s called Ming because she was born in the Ming, during the Ming Dynasty. And unfortunately it doesn’t say here, but that she actually died while they were counting the bands because they were trying to get, really count every band down to the hinge section of it and actually killed, killed the clam. But they, the scientists believe there are clams down there probably 2,000 years old but they haven’t seen them yet.

So, what, we really want to do this in humans, right? We want to, we want to get telomerase produced in all of our cells in a human. And we haven’t done that yet. Otherwise, I wouldn’t be standing here talking about curing aging. It’ll be called cure aging cured. But people have now done this with mice.

Scientists at Harvard University have engineered mice and made it so that when they got really old, they fed him a certain supplement that lengthen their telomeres, and as a result they got younger. So first time in the history of the planet that anybody has successfully reversed aging in any life-form. And the doctor was Dr. Ron De Pinho. He was interviewed by Diane Sawyer on ABC news. I just want to show you the news clipping, it’s about two minutes long.

And now eternal youth, is it in a cage around the corner? News tonight of a breakthrough for some pioneering mice, but we always wonder what does a fountain of youth for rodents reveal for humans? Here’s Sharon Alfonsi reporting.

In the movie Cocoon, it’s a swimming pool that turns back the clock for a group of senior citizens. But now, researchers have found a way, not just to stop, but reverse the aging process. The key is something called a telomere. We all have them, they’re the tips or caps of your chromosomes seen here in yellow. This is what it looks like in a young adult. But as you grow older, the telomeres become damaged and frayed. And as they stop working, we start aging, experiencing things like hearing and memory loss. Sciences took mice who were prematurely aged, added an enzyme and essentially turned their telomeres back on. You can see it, before the enzyme, after. Their brain function improved. Their fertility was restored. It was a remarkable reversal of the aging process. Look at this picture. The mouse on the right has bad skin, gray hair and is balding. But the one on the left had its telomeres flipped back on. And you can see that essentially you now have a dark coat color, that the hair is restored, that the coating has a nice healthy sheen to it. Even more dramatic, the change in five percent of a normal brain, like a patient with severe Alzheimer’s. But after the telomeres were reactivated, the brain returns to normal size. As for humans, while it is just one factor, scientists now say by looking at our blood cells and measuring those telomeres can get a better idea of how well you’ll age. The longer the telomere, the better the chances for a more graceful aging. But as for tinkering with them and turning back our aging process, researchers say they still have a long way to go. Sharon Alfonsi, ABC News, New York.

Well, I think that’s really exciting. I mean as I said it’s the first time this has ever been really done. It has been done by lengthening telomeres. That’s the only change it was made in these mice. The mice got younger by simply lengthening the telomeres.

And you know, me and probably a lot of other people here probably have family members suffering from a lot of age-related diseases. I, my, my father and my younger brother are both suffering from severe Alzheimer’s right now. And this is suggesting that maybe this might even cure Alzheimer’s. The memory of these mice came back suggesting that Alzheimer’s isn’t the loss of memory, but maybe just the loss of access to the memory. And so if we could figure out how to reconnect everything, the memories might come back, just by lengthening the telomeres.

So I’m pretty excited. I’m really anxious to develop something that would actually be potent enough to lengthen telomeres and, and see, and start testing it on people, especially people like my father and stuff. So we can do this in humans but not yet, alright? Because I think we’re close.

That now with the mice, they had to engineer the mice. They actually took a single cell, the mouse, engineered it, so that they could flip the gene…on and off and then they physically shortened the telomeres so the mice would age prematurely. Then they allow these mice to get, then it grew that single cell into an adult mouse. And then bred that mouse and made a colony of mice. And they let these mice get really really old, and they fed it that supplement that turned on the gene and the mice got young again. Now that supplement will not work in humans and it won’t even work in other mice. It only works in these mice. But it is the best support of concept that we’ve ever had that lengthening telomeres in humans will actually make us younger, just like these mice did.

So this is what my company’s all about. My company’s called Sierra Sciences, it’s in Reno, Nevada. Everything we’re doing is trying to figure out a way to produce telomerase in all of our cells to lengthen our telomeres. This is the strategy we’re using. I went one slide too fast here. Ok, so our strategy is to take into account that telomerase, just like every other protein in the human body is made by a gene.

Ok so we have here the gray bar is the chromosome. Remember it’s a hundred million bases in length. Along this DNA is found genes. One of those genes is telomerase. The telomerase gene that functions that is to produce telomerase inside the cell. Now next to every gene, there’s a regulatory element. It’s like a light switch, it turns the gene on and off. In our reproductive cells, that gene is turned on, that switch is turned on. As a result telomerase is being produced. But the reason why it’s shut off in all the other cells of our bodies is because some protein binds to that regulatory element and shuts it off. And as a result, no telomerase is produced. That protein is called a repressor.

So what my company is doing is we’re looking for anything, chemicals, natural products, plants, anything, something shown in green that will bind to that repressor, dislodge it, and allow the gene to turn back on again. Fairly simple, it’s just a lot of work. Ok it’s so, that’s what we’re doing, we’re looking for ways to turn it back on. Now we have found things that do this. Some are very weak, some are a little bit stronger than that, some are a little bit stronger than that. So it’s not quite like the regular light switch. Think of it like a dimmer switch. The dimmer switch now is being turned on and on and on. Well we’ve, we’ve learned now how to turn it on a little bit, okay? We gotta figure out how to turn on even more to be, before start, before we start actually seeing reversal aging. Like we can slow down aging a little bit right now, but we, to actually reverse aging, we have to figure out a way to turn it on a lot.

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Katherine Baltazar

I am a media reporter writing for the Hair, Beauty and Spa Industry. I've been writing and covering salons, beauty products and hair treatments for the pace 5 years.